![]() ![]() ![]() Thus, here, we present a new generation of Incubation of 10 μg/mL of AgPd NPs and AgPt NPs for 1, 3 and 5 days decreased the cancer cell population by 60%. Specifically, the application of 10μg/mL of AgPd NPs and AgPt NPs to bacterial colonies decreased the bacterial population by 99% while presenting no significant cytotoxic effects to human dermal fibroblasts.Īdditionally, anticancer activity was tested with two different kind of cancer cells: melanoma and glioblastoma. coli, we demonstrated remarkable antimicrobial effects for silver palladium (AgPd NPs) and silver platinum (AgPt NPs) nanoparticles. Using colony-forming and growth-curve assays with three different bacteria, S. This composition was selected due to the high antimicrobial effects of silver and the imaging and anticancer properties of palladium and platinum. The composition chosen for the presently fabricated nanoparticles is an alloy of either silver and palladium or silver and platinum. On the other hand, the incorporation of hydrophilic polymers that creates a stealth surface on nanoparticles from opsonization provides them with anticancer properties. ForĮxample, their small size and high surface area allow them to penetrate biofilms as well as bacteria cell walls to influence intracellular mechanisms (such as the function of thiol-containing proteins and reactive oxygen species), therefore, permitting antibacterial activity. The unique size, composition, and functionalization of nanoparticles provides a wide array of therapeutic applications. To address these problems, this thesis pioneered the use of nanoparticles for the treatment of life-threatening bacterial infections and cancer diseases. Also, the use of chemotherapeutics drugs increased the risk of infections, therefore there is a need for the same material to be both antibacterial and anticancer. Global research is working towardsĭeveloping successful cancer therapeutics however, cancer prevalence remains a large problem today. In 2016, 1,685,210 new cases of cancer were diagnosed in the United States alone, leading to 595,690 deaths according to the National Cancer Institute. Another group of diseases that have tremendous impact worldwide is cancer. Immunocompromised patients, there remains limited treatment options to combat these bacteria. Despite the growing prevalence of hospital-acquired bacterial infections, especially in According to the Centers for Disease Control (CDC), in 2017, at least 2 million people in the United States will become infected with drug-resistant bacteria, leading to over 23,000 deaths. The increasing use of antibiotics has led to the emergence of antibiotic resistant bacteria.
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